Through collaborative interdisciplinary studies, CHGR investigators drive the Genetic Research Cycle, a powerful paradigm for disease research applicable to all areas of medicine that begins by comparing human phenotypes and genetic variation to identify sequences of importance to risk or expression of human disease, then moves on to characterizing the biological mechanisms by which these DNA differences lead to differences in disease manifestations using model systems driven by human genotype-phenotype relationships, and is completed when the knowledge gained delivers benefit back to patients and their families through improved diagnosis and prevention, disease management and treatments.
US & Canadian Academy of Pathology (USCAP)